December 1, 2001Journal of Biological ChemistryOpen Access

Differing ADP Release Rates from Myosin Heavy Chain Isoforms Define the Shortening Velocity of Skeletal Muscle Fibers

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Population

Pure myosin isoforms of the four major skeletal muscle myosin types extracted from single rat muscle fibers

Design

Preclinical

Authors

SWStefan WeißUniversity of Kent RRRosetta RossiUniversity of Pavia MPMaria Antonietta PellegrinoUniversity of Pavia

Discussion

Member takes

Implication

May inform skeletal muscle performance differences; leaves open translation to human cardiac or disease contexts.

Structured PICO

Population

Pure myosin isoforms of the four major skeletal muscle myosin types (myosin heavy chains I, IIA, IIX, and IIB) extracted from single rat muscle fibers

Intervention

Flash photolysis using caged-ATP to define the actomyosin dissociation reaction and ADP inhibition

Outcome

Actomyosin dissociation reaction rate and ADP affinity for actomyosin (K(AD))surrogate

The rate of ADP release from myosin heavy chain isoforms limits the maximum shortening velocity of skeletal muscle fibers.

Cite This Study

Weiß et al. (2001) studied this question.

synapsesocial.com/papers/6a71dadeb5c1fe5ca9dfe7a3 https://doi.org/10.1074/jbc.m107434200

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Differing ADP Release Rates from Myosin Heavy Chain Isoforms Define the Shortening Velocity of Skeletal Muscle Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differing ADP Release Rates from Myosin Heavy Chain Isoforms Define the Shortening Velocity of Skeletal Muscle Fibers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider