Why the study?
What is the relationship between plasma norepinephrine and dopamine-beta-hydroxylase activity in patients with congestive heart failure compared to healthy controls and athletes?
Population
90 cardiac patients (NYHA classes I-IV), 85 healthy control subjects, and 18 competitive skiers (total n=193).
Design
Cross-sectional
Authors
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No clinical action warranted in HF; leaves open whether NE-DBH imbalance predicts outcomes or guides therapy.
What is the relationship between plasma norepinephrine and dopamine-beta-hydroxylase activity in patients with congestive heart failure compared to healthy controls and athletes?
There is an inverse relationship between plasma norepinephrine and dopamine-beta-hydroxylase activity that correlates with cardiac status, with higher NE and lower DBH in severe heart failure.
Minami et al. (1983) studied this question.
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