What is the clinical evidence from this study?

Study design: Observational. Population: Chronic renal failure. Intervention: Chronic renal failure on hemodialysis vs. Healthy individuals. Primary outcome: Plasma norepinephrine (NE) level (p=<0.001).

What question did this study set out to answer?

To assess sympathetic nervous system activity in chronic renal failure by evaluating plasma norepinephrine concentrations and dopamine-beta-hydroxylase activity.

January 1, 1979Japanese Circulation Journal-english EditionOpen Access

Plasma Norepinepheine and Dopamine-Beta-Hydoroxylase Activity in Chronic Renal Failure

Q: What are the key findings of this study?

Plasma norepinephrine levels were significantly higher in patients with chronic renal failure on hemodialysis compared to healthy individuals (p<0.001).

Q: What question did this study set out to answer?

To assess sympathetic nervous system activity in chronic renal failure by evaluating plasma norepinephrine concentrations and dopamine-beta-hydroxylase activity.

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Key result

Plasma norepinephrine levels were significantly higher in patients with chronic renal failure on hemodialysis compared to healthy individuals (p<0.001).

Why the study?

Does clonidine reduce plasma norepinephrine levels in patients with chronic renal failure on hemodialysis?

Population

14 patients with chronic renal failure on hemodialysis, and healthy individuals

Comparison

Clonidine hydrochloride 0.30-0.45 mg/day vs Healthy individuals and hemodialysis patients…

Design

Cohort

Authors

MBMasaaki BanShin Nippon Biomedical Laboratories (Japan)TMT Matsuno KOKouichi OgawaHosei University

Discussion

Member takes

Implication

Elevated norepinephrine in hemodialysis patients supports sympathetic hyperactivity; leaves open whether central inhibition improves outcomes.

Key Points

To assess sympathetic nervous system activity in chronic renal failure by evaluating plasma norepinephrine concentrations and dopamine-beta-hydroxylase activity.
Measured plasma norepinephrine using a radioenzymatic assay and dopamine-beta-hydroxylase activity using a photometric assay in healthy individuals and hemodialysis patients (N=14).
Evaluated the effect of central sympathetic inhibition with clonidine hydrochloride (0.30–0.45 mg/day) on plasma norepinephrine levels in hemodialysis patients (n=6).
Plasma norepinephrine levels were significantly higher in hemodialysis patients (N=14) compared to healthy controls (p < 0.001).
Treatment with clonidine hydrochloride significantly decreased plasma norepinephrine levels in hemodialysis patients (n=6, p < 0.05).
Systolic blood pressure positively correlated with plasma norepinephrine in hemodialysis patients not receiving clonidine, who demonstrated high plasma norepinephrine alongside low dopamine-beta-hydroxylase activity.

Study Design

Type

Observational

Structured PICO

Does clonidine reduce plasma norepinephrine levels in patients with chronic renal failure on hemodialysis?

Population

Patients with chronic renal failure on hemodialysis compared to healthy individuals to evaluate sympathetic nervous system activity.

Exposure

Clonidine hydrochloride 0.30-0.45 mg/day (administered to a subset of 6 patients)

Comparator

Healthy individuals (for baseline comparison) and hemodialysis patients not receiving clonidine

Outcome

Plasma norepinephrine (NE) and dopamine-beta-hydroxylase (DBH) activitysurrogate

Main Result

p-value: p=<0.001

Patients with chronic renal failure on hemodialysis have elevated sympathetic nervous system activity, which can be reduced by central sympathetic depressors like clonidine.

Cite This Study

Ban et al. (1979) conducted an observational in Chronic renal failure. Chronic renal failure on hemodialysis vs. Healthy individuals was evaluated on Plasma norepinephrine (NE) level (p=<0.001). Plasma norepinephrine levels were significantly higher in patients with chronic renal failure on hemodialysis compared to healthy individuals (p<0.001).

synapsesocial.com/papers/6a8f96856876bb4413ff62c4 https://doi.org/10.1253/jcj.43.627

Topics

Heart failure HFrEF treatment

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Implication

Elevated norepinephrine in hemodialysis patients supports sympathetic hyperactivity; leaves open whether central inhibition improves outcomes.

Plasma Norepinepheine and Dopamine-Beta-Hydoroxylase Activity in Chronic Renal Failure

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Plasma Norepinepheine and Dopamine-Beta-Hydoroxylase Activity in Chronic Renal Failure

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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Topics

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