What question did this study set out to answer?

To determine whether peripheral vascular changes during reactive hyperemia alter central blood volume measurements obtained from peripheral arterial sampling sites.

November 1, 1961Circulation ResearchOpen Access

A Major Pitfall in the Interpretation of "Central Blood Volume"

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Why the study?

Does the arterial sampling site (brachial vs femoral) affect the calculated "central blood volume" during reactive hyperemia in normal subjects?

Population

Normal subjects undergoing reactive hyperemia of the legs

Comparison

Measurement of "central blood volume" from a… vs Measurement of "central blood volume" from a…

Design

Other

Authors

HMHenry D. McIntoshAmerican College of Cardiology WGWilliam L. GleasonAmerican Heart Association DMDavid MillerAmerican University

Discussion

Member takes

Implication

Peripheral sampling site confounds central blood volume estimates during hyperemia; leaves open valid methods for assessing true central volume shifts.

Key Points

To determine whether peripheral vascular changes during reactive hyperemia alter central blood volume measurements obtained from peripheral arterial sampling sites.
Assessed calculated central blood volume in healthy subjects during reactive hyperemia of the legs using indicator dilution techniques.
Compared hemodynamic values obtained simultaneously or sequentially from brachial arterial and femoral arterial sampling sites.
Calculated central blood volume increased by 569 ml when measured from the brachial artery sampling site during reactive hyperemia.
Calculated central blood volume decreased by 144 ml when measured from the femoral artery sampling site during the same intervention.
Artifacts from peripheral flow distribution can be avoided by injecting the indicator into the right auricle and sampling directly at the root of the aorta.

Structured PICO

Does the arterial sampling site (brachial vs femoral) affect the calculated "central blood volume" during reactive hyperemia in normal subjects?

Population

Normal subjects undergoing reactive hyperemia of the legs

Intervention

Measurement of "central blood volume" from a brachial arterial sampling site

Comparator

Measurement of "central blood volume" from a femoral arterial sampling site

Outcome

Change in calculated "central blood volume"surrogate

Changes in the peripheral arterial system can profoundly confound "central blood volume" measurements taken from peripheral sites, highlighting a major pitfall in its interpretation.

Cite This Study

McIntosh et al. (1961) studied this question.

synapsesocial.com/papers/6a71dd7dc92390ac2d080590 https://doi.org/10.1161/01.res.9.6.1223

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Implication

Peripheral sampling site confounds central blood volume estimates during hyperemia; leaves open valid methods for assessing true central volume shifts.

A Major Pitfall in the Interpretation of "Central Blood Volume"

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

A Major Pitfall in the Interpretation of "Central Blood Volume"

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider