What question did this study set out to answer?

To establish baseline measurements of true cardiopulmonary blood volume in healthy humans and evaluate its physiological variations during leg elevation and exercise.

March 1, 1966CirculationOpen Access

Studies of Cardiopulmonary Blood Volume

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Population

15 normal human subjects

Design

Cross-sectional

Authors

GLGilbert E. LevinsonRutgers, The State University of New Jersey APAlbert D. PacificoProvidence Regional Medical Center Everett MFMartin J. FrankBiognos (Sweden)

Discussion

Member takes

Implication

Provides normative cardiopulmonary blood volume values in healthy adults; leaves open clinical utility and relevance to disease states.

Key Points

To establish baseline measurements of true cardiopulmonary blood volume in healthy humans and evaluate its physiological variations during leg elevation and exercise.
Obtained 81 measurements in 15 healthy human subjects using the Stewart-Hamilton principle, calculating volume as the product of cardiac output and mean transit time from the right atrium to aortic root.
Evaluated subjects across three states: at rest, with legs elevated to bicycle ergometer pedals, and during active exercise.
Resting cardiopulmonary blood volume averaged 422 ml/m² (range 301–546 ml/m²), accounted for 15% of total blood volume, and was significantly higher in males than in females.
Measurements showed high reproducibility (mean discrepancy 25 ml/m², mean coefficient of variation 3.7%) and correlated significantly with stroke volume (r=0.79, P < 0.0001) but not cardiac output.
Leg elevation caused a small, statistically significant increase in cardiopulmonary blood volume, but active exercise produced no further significant volume changes despite increases in cardiac output, heart rate, and stroke volume.

Structured PICO

Population

15 normal human subjects

Intervention

Measurement of cardiopulmonary blood volume using the Stewart-Hamilton principle (product of cardiac output and mean transit time from right atrium to aortic root) at rest, with leg elevation, and during exercise

Outcome

Total cardiopulmonary blood volumesurrogate

This study establishes baseline measurements for true cardiopulmonary blood volume in normal humans, demonstrating its correlation with stroke volume and stability during exercise.

Cite This Study

Levinson et al. (1966) studied this question.

synapsesocial.com/papers/6a74719980fadadbba090dcb https://doi.org/10.1161/01.cir.33.3.347

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March 1, 1966CirculationOpen Access

Studies of Cardiopulmonary Blood Volume

View Full Paper

Ask AI

Bookmark

Population

15 normal human subjects

Design

Cross-sectional

Authors

GLGilbert E. LevinsonRutgers, The State University of New Jersey APAlbert D. PacificoProvidence Regional Medical Center Everett MFMartin J. FrankBiognos (Sweden)

Discussion

Member takes

Implication

Provides normative cardiopulmonary blood volume values in healthy adults; leaves open clinical utility and relevance to disease states.

Key Points

To establish baseline measurements of true cardiopulmonary blood volume in healthy humans and evaluate its physiological variations during leg elevation and exercise.
Obtained 81 measurements in 15 healthy human subjects using the Stewart-Hamilton principle, calculating volume as the product of cardiac output and mean transit time from the right atrium to aortic root.
Evaluated subjects across three states: at rest, with legs elevated to bicycle ergometer pedals, and during active exercise.
Resting cardiopulmonary blood volume averaged 422 ml/m² (range 301–546 ml/m²), accounted for 15% of total blood volume, and was significantly higher in males than in females.
Measurements showed high reproducibility (mean discrepancy 25 ml/m², mean coefficient of variation 3.7%) and correlated significantly with stroke volume (r=0.79, P < 0.0001) but not cardiac output.
Leg elevation caused a small, statistically significant increase in cardiopulmonary blood volume, but active exercise produced no further significant volume changes despite increases in cardiac output, heart rate, and stroke volume.

Structured PICO

Population

15 normal human subjects

Intervention

Outcome

Total cardiopulmonary blood volumesurrogate

This study establishes baseline measurements for true cardiopulmonary blood volume in normal humans, demonstrating its correlation with stroke volume and stability during exercise.

Cite This Study

Levinson et al. (1966) studied this question.

synapsesocial.com/papers/6a74719980fadadbba090dcb https://doi.org/10.1161/01.cir.33.3.347

Also Consider

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