What question did this study set out to answer?

To evaluate pulmonary blood volume and cardiac output in healthy individuals under resting and physically altered states using external radiotracer detection.

January 1, 1961Nuklearmedizin - NuclearMedicine

Observations on Cardiac Output and ”Pulmonary Blood Volume” in Normal Man by External Recording of the Intracardiac Flow of 131I Labelled Albumin

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Normal subjects. Intervention: Physiological stress (digestion, exercise, alarm) vs. Basal state. Primary outcome: Pulmonary blood volume and cardiac output.

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Key result

External recording of 131I labelled albumin flow showed basal pulmonary blood volume is 28.2% of total blood volume, decreasing by 6.3% during digestion and 4.5% during exercise.

Key Points

To evaluate pulmonary blood volume and cardiac output in healthy individuals under resting and physically altered states using external radiotracer detection.
Tracked the transit of intravenously administered 131I labelled human serum albumin across the heart chambers using external scintillation recording.
Calculated basal cardiac output, mean transit time from the right to left heart, and pulmonary blood volume relative to total blood volume during rest, digestion, exercise, and emotional alarm.
Basal pulmonary blood volume in normal subjects averaged 28.2 ± 0.6% of total blood volume, with no correlation observed between resting cardiac output and pulmonary blood volume.
Digestion and exercise increased cardiac output while reducing pulmonary blood volume by 6.3 ± 1.2% (~280 ml) and 4.5 ± 1.0% (~200 ml) of total blood volume, respectively.
Elevations in cardiac output induced by alarm did not decrease pulmonary blood volume and instead showed a trend toward an increase.

Study Design

Type

Observational

Structured PICO

Population

Normal subjects evaluated for cardiac output and pulmonary blood volume in the basal state, during digestion, exercise, and alarm.

Exposure

External recording of the intracardiac flow of 131I labelled human serum albumin

Outcome

Cardiac output and pulmonary blood volumesurrogate

This physiological study demonstrates that pulmonary blood volume decreases during physiological increases in cardiac output such as digestion and exercise, but not during alarm.

Discussion

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Implication

Pulmonary blood volume may adjust dynamically with cardiac output; extends foundational physiology but leaves open validation in disease states.

Cite This Study

Lammerant et al. (1961) conducted an observational in Normal subjects. Physiological stress (digestion, exercise, alarm) vs. Basal state was evaluated on Pulmonary blood volume and cardiac output. External recording of 131I labelled albumin flow showed basal pulmonary blood volume is 28.2% of total blood volume, decreasing by 6.3% during digestion and 4.5% during exercise.

synapsesocial.com/papers/6a6f1663a2d7cf2e39c28759 https://doi.org/10.1055/s-0037-1621159

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Implication

Pulmonary blood volume may adjust dynamically with cardiac output; extends foundational physiology but leaves open validation in disease states.

Observations on Cardiac Output and ”Pulmonary Blood Volume” in Normal Man by External Recording of the Intracardiac Flow of 131I Labelled Albumin

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Observations on Cardiac Output and ”Pulmonary Blood Volume” in Normal Man by External Recording of the Intracardiac Flow of 131I Labelled Albumin

Key Points

Study Design

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider