Probucol can induce torsades de pointes in patients with pre-existing long QT intervals, highlighting the need for caution and ECG monitoring when prescribing this drug to such patients.
May warrant ECG caution with probucol in long-QT patients; single case leaves broader risk assessment open.
Probucol administration of 4 weeks produced torsades de pointes associated with exacerbated QT interval prolongation in a 36-year-old woman with Romano-Ward syndrome. With discontinuance of probucol, the QT interval corrected for rate shortened from 620 msec to 500 msec and ventricular ectopic beats disappeared completely. Although probucol is known to prolong the QT interval, associated ventricular tachyarrhythmia has not been reported in humans as yet. This case suggests that one should be very careful in the administration of probucol to patients with long baseline QT intervals.
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Matsuhashi et al. (1989) studied this question.
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