Key result
Lacidipine 4 mg significantly lowered systolic and diastolic blood pressure at baseline and during or after exercise compared to placebo in patients with mild to moderate hypertension.
Why the study?
Does lacidipine 4 mg once daily reduce blood pressure during and after physical effort in patients with mild to moderate hypertension?
RCT (n=18)
double-blind
crossover
No
Does lacidipine 4 mg once daily reduce blood pressure during and after physical effort in patients with mild to moderate hypertension?
Lacidipine 4 mg effectively lowers blood pressure during rest and physical exertion in mild to moderate hypertension without increasing myocardial oxygen demand.
Supports lacidipine 4 mg for BP control in active patients with mild-moderate hypertension; extends resting data to exercise conditions.
The aim of this study was to evaluate the effects of chronic treatment with lacidipine on blood pressure, heart rate and double product during and immediately after physical effort in mild to moderate hypertensive patients. This was a single-center, randomized, double-blind, crossover, placebo-controlled clinical trial. Eighteen hypertensive patients (56% males, median age 53 years) were randomized to lacidipine 4 mg o.i.d. followed by placebo or to placebo followed by lacidipine 4 mg o.i.d. Lacidipine compared with placebo exerted a significant antihypertensive effect, lowering SBP and DBP both at baseline and either during or after exercise test. The average incremental changes of SBP and DBP between pre-exercise stage and maximal effort did not show any significant differences between treatments. HR during treatment with lacidipine was higher than during treatment with placebo both at rest and after exercise, but at maximal effort, HR was not different from placebo. The average values of DP at maximal effort, and during recovery, did not show any significant differences. Lacidipine 4 mg was effective in lowering blood pressure and in maintaining its antihypertensive effect throughout and after physical exercise, without enhancing double product value, which is an indirect index of myocardial oxygen consumption.
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Rossi et al. (2002) conducted an RCT in mild to moderate hypertension (n=18). Lacidipine vs. Placebo was evaluated on blood pressure, heart rate and double product during and immediately after physical effort. Lacidipine 4 mg significantly lowered systolic and diastolic blood pressure at baseline and during or after exercise compared to placebo in patients with mild to moderate hypertension.
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