Why the study?
Does lacidipine improve peak oxygen consumption, hemodynamics, and neurohormones in patients with mild to moderate chronic heart failure?
Population
25 outpatients with symptoms of mild to moderate chronic heart failure despite treatment with diuretics…
Comparison
Lacidipine 4 mg once daily for 8 weeks. vs Placebo for 8 weeks.
Design
RCT, parallel group, double blind
Follow-up
8 weeks
Authors
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Supports adjunctive lacidipine for functional gains in mild-moderate HF on standard therapy; extends hemodynamic data to exercise capacity.
Does lacidipine improve peak oxygen consumption, hemodynamics, and neurohormones in patients with mild to moderate chronic heart failure?
Lacidipine 4 mg daily significantly improved peak oxygen consumption and hemodynamics without adverse neurohormonal activation in patients with mild to moderate heart failure.
Vries et al. (1996) studied this question.
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