December 1, 1997Hypertension
Lacidipine Restores Endothelium-Dependent Vasodilation in Essential Hypertensive Patients
Why the study?
Does lacidipine improve endothelium-dependent vasodilation in patients with essential hypertension?
Population
31 subjects total: 19 patients with essential hypertension and 12 normotensive control subjects.
Comparison
Lacidipine 6 mg/day orally for 8 weeks and 32… vs Baseline measurements and normotensive control…
Design
Cohort
Follow-up
32 weeks
Authors
Discussion
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Implication
Lacidipine may improve endothelium-dependent vasodilation in hypertension; hypothesis-generating and should not change practice without randomized confirmation.
Structured PICO
Does lacidipine improve endothelium-dependent vasodilation in patients with essential hypertension?
P
Population
31 subjects total: 19 patients with essential hypertension (mean age 49.4+/-10.2 years) and 12 normotensive control subjects (mean age 47.8+/-8.6 years).
I
Intervention
Lacidipine 6 mg/day orally for 8 weeks and 32 weeks.
C
Comparator
Baseline (pre-treatment) measurements and normotensive control subjects.
O
Outcome
Forearm blood flow modifications (vascular resistance) induced by intrabrachial infusion of acetylcholine, bradykinin, and sodium nitroprusside.surrogate
Lacidipine treatment restores endothelium-dependent vasodilation in patients with essential hypertension, suggesting a beneficial effect on endothelial function.
Cite This Study
Taddei et al. (1997) studied this question.