Why the study?
Does lacidipine reduce oxidative stress and alter melatonin levels in patients with essential hypertension?
Population
25 subjects (14 patients with essential hypertension and 11 healthy subjects)
Comparison
Lacidipine 4 mg/day for 6 months vs Baseline values before treatment and healthy…
Design
Cohort
Follow-up
6 months
Authors
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Lacidipine was associated with reduced oxidative stress and normalized melatonin in hypertension; hypothesis-generating and requires randomized confirmation before practice change.
Does lacidipine reduce oxidative stress and alter melatonin levels in patients with essential hypertension?
Lacidipine reduces blood pressure and oxidative stress in hypertensive patients, potentially avoiding endothelial damage.
Escames et al. (2004) studied this question.
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