Why the study?
The study investigated the effects of lacidipine on clinic and ambulatory blood pressure and arterial stiffness compared with amlodipine in patients with mild-to-moderate hypertension.
Does lacidipine reduce 24-h ambulatory systolic BP in patients with mild-to-moderate hypertension compared to amlodipine?
Population
269 patients aged 50–80 years with mild-to-moderate clinic hypertension
Comparison
Lacidipine (4–6 mg/day) vs amlodipine (5–7.5 mg/day)
Design
Randomised, double-blind, double-dummy trial
Follow-up
20 weeks
Authors
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Lacidipine matches amlodipine for BP reduction and arterial stiffness improvement; confirms CCB equivalence in mild-to-moderate hypertension.
Does lacidipine reduce 24-h ambulatory systolic BP in patients with mild-to-moderate hypertension compared to amlodipine?
Lacidipine is as effective as amlodipine in lowering clinic and ambulatory blood pressure and improving arterial stiffness in patients with mild-to-moderate hypertension.
Wang et al. (2020) studied this question.
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