November 4, 2002Circulation
Calcium Antagonist Lacidipine Slows Down Progression of Asymptomatic Carotid Atherosclerosis
Why the study?
Does lacidipine reduce carotid atherosclerosis progression in patients with hypertension compared to atenolol?
Population
2334 patients with hypertension
Comparison
Lacidipine for 4 years vs Atenolol for 4 years
Design
RCT, randomized, double-blind
Follow-up
4 years
Authors
Discussion
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Member takes
Implication
Supports lacidipine over atenolol to slow carotid atherosclerosis progression in hypertension; extends evidence for CCB effects beyond BP lowering.
Structured PICO
Does lacidipine reduce carotid atherosclerosis progression in patients with hypertension compared to atenolol?
P
Population
2334 patients with hypertension
I
Intervention
Lacidipine for 4 years
C
Comparator
Atenolol for 4 years
O
Outcome
Mean of the maximum intima-media thicknesses (IMT) in far walls of common carotids and bifurcations (CBM(max)) over 4 yearssurrogate
Lacidipine slows the progression of carotid atherosclerosis in hypertensive patients more effectively than atenolol, independent of its blood pressure-lowering effects.
Cite This Study
Zanchetti et al. (2002) studied this question.