May 12, 2004Journal of Hypertension
Absolute and relative changes in carotid intima???media thickness and atherosclerotic plaques during long-term antihypertensive treatment
Key result
Lacidipine slowed the progression of carotid atherosclerosis significantly more than atenolol over 4 years of treatment in hypertensive patients.
Why the study?
Does lacidipine reduce the progression of carotid atherosclerosis compared to atenolol in hypertensive patients?
Population
2,334 hypertensive patients
Comparison
Lacidipine for 4 years vs Atenolol for 4 years
Design
RCT, randomized, double-blind
Follow-up
4 years
Authors
Discussion
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Implication
Supports lacidipine over atenolol to slow carotid atherosclerosis in hypertension; extends antihypertensive comparisons to vascular structural outcomes.
Study Design
Type
RCT (n=2,334)
Blinding
Double-blind
Randomization
Randomized
Structured PICO
Does lacidipine reduce the progression of carotid atherosclerosis compared to atenolol in hypertensive patients?
P
Population
2,334 hypertensive patients followed for 4 years to assess carotid atherosclerosis progression.
I
Intervention
Lacidipine for 4 years
C
Comparator
Atenolol for 4 years
O
Outcome
Progression of carotid atherosclerosis (CBMmax measured on the four far walls of common carotids and bifurcations)surrogate
Lacidipine slows the progression of carotid atherosclerosis significantly more than atenolol in hypertensive patients, though accurate assessment of absolute changes requires longitudinal quality control of ultrasound readings.
Limitations
- Absolute treatment-related changes cannot safely be judged by readings made during a long-term study unless a longitudinal quality control of readings is performed.
Cite This Study
Zanchetti et al. (2004) conducted an RCT in Hypertension (n=2,334). Lacidipine vs. Atenolol was evaluated on Progression of carotid atherosclerosis (CBMmax). Lacidipine slowed the progression of carotid atherosclerosis significantly more than atenolol over 4 years of treatment in hypertensive patients.