August 1, 2001Journal of Hypertension
Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients
Why the study?
Does lacidipine improve endothelium-dependent vasodilation and reduce oxidative stress compared to atenolol in essential hypertensive patients?
Population
20 essential hypertensive patients and 10 healthy subjects
Comparison
Lacidipine (4-6 mg/daily) for 12 weeks vs Atenolol (50-100 mg/daily) for 12 weeks
Design
RCT, randomized
Follow-up
12 weeks
Authors
Discussion
Loading...
Member takes
Implication
May favor lacidipine for endothelial protection in hypertension; extends RCT evidence on differential effects versus beta-blockers.
Structured PICO
Does lacidipine improve endothelium-dependent vasodilation and reduce oxidative stress compared to atenolol in essential hypertensive patients?
P
Population
20 essential hypertensive patients and 10 healthy subjects
I
Intervention
Lacidipine (4-6 mg/daily) for 12 weeks
C
Comparator
Atenolol (50-100 mg/daily) for 12 weeks
O
Outcome
Forearm blood flow modifications induced by intrabrachial acetylcholine, bradykinin, and sodium nitroprusside in the absence and presence of L-NMMAsurrogate
Lacidipine, a calcium antagonist, improves endothelium-dependent vasodilation in essential hypertension by restoring nitric oxide availability, likely through antioxidant mechanisms, an effect not seen with atenolol.
Cite This Study
Taddei et al. (2001) studied this question.