Key result
Amlodipine was more effective in promoting beneficial autonomic cardiovascular adaptations in sedentary rats, while enalapril achieved better results when combined with aerobic physical training.
Why the study?
Does amlodipine or enalapril, with or without aerobic physical training, improve cardiovascular autonomic control in spontaneously hypertensive rats?
Population
18-week-old spontaneously hypertensive rats (n=48)
Comparison
Amlodipine or enalapril for 10 weeks, with or… vs Vehicle control, with or without a 10-week…
Design
Preclinical
Follow-up
10 weeks
Authors
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No immediate change to hypertension management; leaves open translation of activity-dependent autonomic effects from rats to patients.
Does amlodipine or enalapril, with or without aerobic physical training, improve cardiovascular autonomic control in spontaneously hypertensive rats?
In a spontaneously hypertensive rat model, amlodipine improved autonomic cardiovascular adaptations in sedentary animals, whereas enalapril required combination with aerobic training to achieve similar autonomic benefits.
Maida et al. (2016) studied Hypertension (spontaneously hypertensive rats) (n=48). Amlodipine and enalapril vs. Control (vehicle group) was evaluated on Autonomic and hemodynamic cardiovascular effects (arterial pressure, heart rate variability, baroflex sensitivity). Amlodipine was more effective in promoting beneficial autonomic cardiovascular adaptations in sedentary rats, while enalapril achieved better results when combined with aerobic physical training.
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