Why the study?
Does enalapril or hydralazine alter the short-term variability of blood pressure and heart rate in conscious Wistar rats?
Population
Conscious Wistar rats
Comparison
Enalapril or hydralazine vs Saline or distilled water
Design
Preclinical
Follow-up
12 days (chronic protocol)
Authors
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Hypothesis-generating for sympathetic modulation by chronic enalapril in rats; leaves open translation to human BP variability.
Does enalapril or hydralazine alter the short-term variability of blood pressure and heart rate in conscious Wistar rats?
Chronic ACE inhibition with enalapril reduces blood pressure variability and low-frequency oscillations in rats, suggesting reduced sympathetic outflow to vascular smooth muscles.
Grichois et al. (1992) studied this question.
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