Why the study?
Does alprenolol alter oxygen consumption and central hemodynamics in men with untreated early essential hypertension?
Population
10 men with untreated early essential hypertension
Comparison
Alprenolol, 400–800 mg daily for one year vs Baseline (before therapy)
Design
Cohort
Follow-up
1 year
Authors
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Alprenolol-associated hemodynamics in early hypertension should not change practice; leaves open outcome impact versus resistance-lowering agents.
Does alprenolol alter oxygen consumption and central hemodynamics in men with untreated early essential hypertension?
Long-term alprenolol therapy in early essential hypertension reduces heart rate, cardiac index, and blood pressure without reducing total peripheral resistance.
Per Lund‐Johansen (1974) studied this question.
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