January 1, 1976Clinical Science
Haemodynamic Long-Term Effects of β-Receptor-Blocking Agents in Hypertension: A Comparison between Alprenolol, Atenolol, Metoprolol and Timolol
Key result
Beta-blockers linked to reduced resting MAP and HR in men with essential hypertension.
- n=51
Why the study?
The haemodynamic long-term effects of different beta-receptor-blocking agents in patients with essential hypertension were not fully characterized and compared.
Do different beta-receptor-blocking agents have differing long-term haemodynamic effects in men with mild to moderate essential hypertension?
Comparison
Alprenolol vs atenolol vs metoprolol vs timolol
Design
Observational cohort study
Follow-up
1 year
Authors
Discussion
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Implication
Beta-blockers lower BP and HR at rest and exercise in stage I hypertension; leaves open effects on oxygen consumption.
Study Design
Type
Observational (n=51)
Structured PICO
Do different beta-receptor-blocking agents have differing long-term haemodynamic effects in men with mild to moderate essential hypertension?
P
Population
51 men with essential hypertension (W.H.O. stage I) evaluated at rest and during exercise, followed for 1 year on beta-blocker therapy.
E
Exposure
Single-drug therapy with a beta-receptor-blocking agent: alprenolol (n=10), atenolol (n=13), metoprolol (n=12), or timolol (n=16) for 1 year
C
Comparator
Active comparators (head-to-head comparison between alprenolol, atenolol, metoprolol, and timolol)
O
Outcome
Oxygen consumption and central haemodynamics (including mean arterial pressure, heart rate, stroke volume, cardiac index, and total peripheral resistance) at rest and during exercise after 1 yearsurrogate
Different beta-blockers produce similar major long-term haemodynamic improvements in mild to moderate essential hypertension, with only minor differences in stroke volume and peripheral resistance.
Cite This Study
Lund‐Johansen et al. (1976) conducted an observational in Essential hypertension (W.H.O. stage I) (n=51). Beta-receptor-blocking agents (alprenolol, atenolol, metoprolol, timolol) vs. Baseline was evaluated on Mean arterial pressure and heart rate. Beta-receptor-blocking agents significantly reduced mean arterial pressure by 11-18% and heart rate by 20-28% at rest after 1 year in men with essential hypertension.