Why the study?
Does alprenolol alter haemodynamic and metabolic responses to prolonged exercise in untreated hypertensive males?
Does alprenolol alter haemodynamic and metabolic responses to prolonged exercise in untreated hypertensive males?
Long-term alprenolol treatment in hypertensive men reduces blood pressure and heart rate during exercise without compromising cardiac output or exercise leg blood flow, though it alters metabolic responses.
Alprenolol was associated with lower BP and HR during exercise without reducing cardiac output in hypertensive men; leaves open metabolic impacts on long-term outcomes.
Central and regional haemodynamics and leg metabolism at rest, during and after a prolonged exercise were studied in seven untreated hypertensive males before and after a long-term treatment (6 weeks) with an unselective beta-receptor-blocking drug (alprenolol). 2. Alprenolol treatment (200-400 mg, twice daily) decreased arterial blood pressure at rest and during exercise; it reduced heart rate in relation to drug plasma concentrations during and after exercise; it left cardiac output unchanged; it reduced leg blood flow at rest, but had no effect on leg blood flow during exercise. 3. Alprenolol treatment also decreased lipolysis and lactate release in relation to drug plasma concentrations during exercise.
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Frisk‐Holmberg et al. (1976) studied this question.
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