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May 15, 2001CirculationOpen Access

l -Arginine and S -Nitrosoglutathione Reduce Embolization in Humans

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Why the study?

Does intravenous L-arginine or S-nitrosoglutathione reduce cerebral embolization in patients undergoing carotid endarterectomy?

Population

42 patients undergoing carotid endarterectomy, pretreated with aspirin and given heparin during surgery.

Comparison

L-arginine or S-nitrosoglutathione administered… vs Placebo administered intravenously for 90…

Design

RCT, randomized, double-blind

Follow-up

24 hours

Authors

ZKZoltán KáposztaJahn Ferenc Dél-Pesti Kórház és RendelőintézetPBPaul BaskervilleKing's College HospitalDMDavid J. MadgeXention (United Kingdom)

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Implication

Supports adjunctive use to curb embolization in carotid endarterectomy; extends nitric oxide donor evidence to perioperative cerebrovascular protection.

Structured PICO

Does intravenous L-arginine or S-nitrosoglutathione reduce cerebral embolization in patients undergoing carotid endarterectomy?

P
Population
42 patients undergoing carotid endarterectomy, pretreated with aspirin and given heparin during surgery.
I
Intervention
L-arginine (n=14) or S-nitrosoglutathione (GSNO) (n=14) administered intravenously for 90 minutes, starting 30 minutes after skin closure.
C
Comparator
Placebo (n=14) administered intravenously for 90 minutes. All patients received background aspirin and heparin.
O
Outcome
Number of Doppler embolic signals detected by transcranial Doppler from the ipsilateral middle cerebral artery during the first 4 hours after surgery.surrogate

Intravenous L-arginine and S-nitrosoglutathione significantly reduce cerebral embolic signals detected by Doppler ultrasound following carotid endarterectomy.

Cite This Study

Káposzta et al. (2001) studied this question.

synapsesocial.com/papers/6a71e24c31a3df824329db08https://doi.org/10.1161/01.cir.103.19.2371

Topics

Dual antiplatelet therapy
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Also Consider

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  1. 1Endogenous nitric oxide protects against platelet aggregation and cyclic flow variations in stenosed and endothelium-injured arteries.1992 · 199 citations
  2. 2The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans.1984 · 66 citations
  3. 3Dietary l-Arginine Supplementation Normalizes Platelet Aggregation in Hypercholesterolemic Humans1997 · 171 citations
  4. 4Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.1996 · 417 citations
  5. 5Effects of S-nitroso-glutathione in the human forearm circulation: evidence for selective inhibition of platelet activation1994 · 169 citations