Key result
Use of any antipsychotic drug was associated with an increased risk of out-of-hospital cardiac arrest (OR 1.53; 95% CI 1.23-1.89), driven by typical antipsychotics and quetiapine.
Why the study?
Does antipsychotic drug use increase the risk of out-of-hospital cardiac arrest?
Case-Control (n=28,947)
Does antipsychotic drug use increase the risk of out-of-hospital cardiac arrest?
Odds Ratio: 1.53 (95% CI 1.23–1.89)
The use of typical antipsychotics and specific drugs like haloperidol, levomepromazine, and quetiapine is associated with a significantly increased risk of out-of-hospital cardiac arrest.
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Warrants caution with typical antipsychotics and quetiapine; leaves open causality in this observational analysis.
Weeke et al. (2014) conducted a case-control in Out-of-hospital cardiac arrest (n=28,947). Antipsychotic drugs vs. No antipsychotic drug use was evaluated on Out-of-hospital cardiac arrest (OR 1.53, 95% CI 1.23-1.89). Use of any antipsychotic drug was associated with an increased risk of out-of-hospital cardiac arrest (OR 1.53; 95% CI 1.23-1.89), driven by typical antipsychotics and quetiapine.
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