Why the study?
Does prolonged intragraft urokinase infusion with a new multiside hole infusion catheter improve procedural safety and outcomes in patients with aged saphenous vein grafts undergoing balloon angioplasty?
Does prolonged intragraft urokinase infusion with a new multiside hole infusion catheter improve procedural safety and outcomes in patients with aged saphenous vein grafts undergoing balloon angioplasty?
Prolonged intragraft urokinase infusion using a multiside hole catheter may be an effective strategy to reduce thrombus burden and prevent complications during angioplasty of aged saphenous vein grafts.
Patients with aged saphenous vein grafts and recurrent symptoms of angina are being seen with increasing frequency [Bourassa: J Am Coll Cardiol 17:1081-1083, 1991]. The treatment of these patients remains a dilemma. Direct balloon angioplasty is frequently complicated by distal embolization and early restenosis [Aureran and Gruentzig: Am J Cardiol 53:953-954, 1984]. There is evidence that thrombus plays a significant role in this occlusive process [Hartmann et al.: J Am Coll Cardiol 18:1517-1523, 1991]. Prolonged intragraft urokinase infusion with a new multiside hole infusion catheter debulks thrombus and permits balloon angioplasty without the usual complications.
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Cundey et al. (1994) studied this question.
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