Key result
Local urokinase delivery via the Dispatch catheter increased mean minimal lumen diameter from 0.34 mm to 1.81 mm (P<0.01) and reduced mean thrombus score from 2.3 to 0.3 (P<0.01).
Why the study?
Does local urokinase delivery via the Dispatch catheter improve angiographic outcomes in patients with thrombotic saphenous vein bypass grafts?
Does local urokinase delivery via the Dispatch catheter improve angiographic outcomes in patients with thrombotic saphenous vein bypass grafts?
p-value: p=<0.01
Local urokinase delivery via the Dispatch catheter prior to percutaneous intervention in thrombotic saphenous vein grafts significantly improves minimal lumen diameter and reduces thrombus burden.
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May facilitate PCI in thrombotic SVGs; hypothesis-generating and requires randomized confirmation before clinical adoption.
Glazier et al. (1997) studied Unstable or postinfarction angina (n=13). Local urokinase delivery with the Dispatch catheter was evaluated on Mean minimal lumen diameter (p=<0.01). Local urokinase delivery via the Dispatch catheter increased mean minimal lumen diameter from 0.34 mm to 1.81 mm (P<0.01) and reduced mean thrombus score from 2.3 to 0.3 (P<0.01).
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