December 26, 2013Clinical and Vaccine ImmunologyOpen Access

Estimates of Mumps Seroprevalence May Be Influenced by Antibody Specificity and Serologic Method

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Population

Individuals tested for mumps antibodies (specific demographics and sample size not stated)

Design

Other

Authors

DLDonald R. LatnerHudsonAlpha Institute for Biotechnology MMMarcia McGrewCenters for Disease Control and Prevention NWNobia J. WilliamsCenters for Disease Control and Prevention

Discussion

Member takes

Implication

Mumps seroprevalence may be overestimated by whole-virus ELISAs; leaves open optimal neutralizing correlates for vaccine and immunity studies.

Structured PICO

Population

Individuals tested for mumps antibodies (specific demographics and sample size not stated)

Intervention

Measurement of mumps antibody levels by plaque reduction neutralization, commercial ELISA (whole-virus antigen), and ELISAs specific for mumps nucleoprotein and hemagglutinin

Outcome

Correlation between mumps neutralization titers and ELISA measurementssurrogate

Previous estimates of mumps immunity based on whole-virus ELISAs may be overstated due to poor correlation with neutralizing antibody levels.

Cite This Study

Latner et al. (2013) studied this question.

synapsesocial.com/papers/6a71ead931a3df824329def2 https://doi.org/10.1128/cvi.00621-13

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Implication

Mumps seroprevalence may be overestimated by whole-virus ELISAs; leaves open optimal neutralizing correlates for vaccine and immunity studies.

Estimates of Mumps Seroprevalence May Be Influenced by Antibody Specificity and Serologic Method

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Estimates of Mumps Seroprevalence May Be Influenced by Antibody Specificity and Serologic Method

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider