New tests for characterization of mumps virus antibodies: hemolysis inhibition, single radial immunodiffusion with immobilized virions, and mixed hemadsorption

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Population

Rabbit hyperimmune sera against mumps and early and late human convalescent sera

Comparison

Hemolysis inhibition, single radial… vs Hemagglutination inhibition (HI) test

Design

Preclinical

Authors

Discussion

May support SRID and mixed hemadsorption for mumps serology research; leaves open clinical adoption pending human validation.

Population

Rabbit hyperimmune sera against mumps and early and late human convalescent sera

Intervention

Hemolysis inhibition (HLI), single radial immunodiffusion (SRID) with immobilized virions, and mixed hemadsorption tests

Comparator

Hemagglutination inhibition (HI) test

Outcome

Measurement of antibodies against mumps virus (hemagglutinin and hemolysin)surrogate

SRID is recommended for identifying acute mumps infection due to its simplicity, while mixed hemadsorption is suitable for immunity screening.

Norrby et al. (1977) studied this question.

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