Population
C2 mouse myoblasts (clone C2.7)
Comparison
Transfection with sense and antisense RLI cDNA… vs Transfection with empty vector (pcDNA3neo)
Design
Preclinical
Authors
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Supports RNase L role in myoblast differentiation; hypothesis-generating for muscle biology and requires in vivo validation.
RNase L is directly involved in myoblast differentiation by regulating MyoD mRNA stability, identifying a novel mRNA target for RNase L.
Bisbal et al. (2000) studied this question.
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