This case report highlights that primary angiosarcoma of the breast can be complicated by DIC, which can be successfully managed with substitution therapy to allow for surgical resection.
Substitution therapy may enable resection in DIC-complicated breast angiosarcoma; hypothesis-generating from one case, larger studies needed.
Primary angiosarcoma of the breast (PAB) accounts for 0.04% of all breast malignant tumors. It affects young women usually at third or fourth decades of life. PAB clinically manifests as a painless, movable mass with sharp limits. A bluish red discoloration of the overlying skin is often observed. Enlargement of axillary lymph nodes generally does not occur. Angiosarcoma of the breast has a very poor prognosis due to the tendency to metastasize haematogenously and high frequency of local recurrence. Mastectomy and chemotherapy are preferable treatment choices. This paper presents a case of primary angiosarcoma of the breast with a syndrome of disseminated intravascular coagulation (DIC).
No takes yet. Share an insight, caveat, or question.
Alexandrova et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: