Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 10, 1994FEBS LettersOpen Access

Molecular cloning and chromosomal localization of the human thrombopoietin gene

View Full Paper
Ask AI
Bookmark
Share

Population

Human genomic library and COS-1 cells

Design

Preclinical

Authors

YSYoshiaki SohmaKyowa Kirin (Japan)HAHiromichi AkahoriGifu UniversityNSNaohiko SekiChiba University

Discussion

Loading...

Member takes

Implication

Enables molecular studies of thrombopoiesis; leaves open therapeutic translation in thrombocytopenia.

Structured PICO

P
Population
Human genomic library and COS-1 cells
I
Intervention
Molecular cloning, sequencing, and chromosomal localization of the human thrombopoietin (TPO) gene
O
Outcome
Gene structure, copy number, transcription initiation site, and chromosomal location

This basic science study successfully cloned the human thrombopoietin gene, determined its structure, and mapped it to chromosome 3q27.

Cite This Study

Sohma et al. (1994) studied this question.

synapsesocial.com/papers/6a71efab75498292b70b3b93https://doi.org/10.1016/0014-5793(94)01008-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding2008 · 199 citations
  2. 2Ligand-induced activation of chimeric receptors between the erythropoietin receptor and receptor tyrosine kinases.1994 · 88 citations
  3. 3High efficiency polyoma DNA transfection of chloroquine treated cells1983 · 713 citations
  4. 4Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.1978 · 1,138 citations