Why the study?
Is the degree of polypharmacy associated with health-related quality of life in older American Indians?
Is the degree of polypharmacy associated with health-related quality of life in older American Indians?
Higher degrees of polypharmacy are independently associated with lower physical health-related quality of life among older American Indians.
Polypharmacy was associated with lower physical HRQoL in older American Indians; hypothesis-generating for deprescribing trials before practice change.
This cross-sectional study examines the relationship of polypharmacy to health-related quality of life (HRQoL) among a group of older American Indians. An in-home interview and survey were administered to 63 community-dwelling American Indians aged 50 or older who were taking four or more prescription medications regularly. With the component summary scores from the Medical Outcomes Study Short Form-36 instrument analyzed as dependent variables, only the Physical Component Summary (PCS) score (r = .30, p = .02), and not the Mental (r = .06, p = .67), was associated with degree of polypharmacy. This association with PCS score remained significant even after controlling for age, sex, and chronic disease score (adjusted β = -.91, p = .045). This study is the first to describe the relationship between polypharmacy and HRQoL among a group of American Indians, and the results support the need for larger and more comprehensive studies of medication use in this special population.
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Henderson et al. (2006) studied this question.
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