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October 16, 2022CureusOpen Access

Cross-Sectional Observational Study on Association of Polypharmacy With Health-Related Quality of Life in Patients With Hypertension

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Why the study?

Hypertension management in elderly patients often involves multiple co-morbidities leading to increased polypharmacy, highlighting the need to identify its impact on health-related quality of life.

Does polypharmacy reduce health-related quality of life in patients with hypertension?

Population

100 hypertensive patients at a rural tertiary care hospital in Wardha District

Comparison

Polypharmacy vs non-polypharmacy based on number of medications

Design

Cross-sectional observational study

Authors

TPTanisha ParambaSZSarju Zilate

Discussion

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Implication

Polypharmacy was associated with lower HRQoL in hypertension; hypothesis-generating and requires prospective confirmation before practice change.

Structured PICO

Does polypharmacy reduce health-related quality of life in patients with hypertension?

P
Population
100 patients clinically diagnosed with hypertension and prescribed allopathic medication at a rural tertiary care hospital in Wardha District, India.
I
Intervention
Polypharmacy (higher number of medications)
C
Comparator
Lower number of medications (non-polypharmacy)
O
Outcome
Physical Component Score (PCS) and Mental Component Score (MCS) of the Health-Related Quality of Life (HRQoL) assessed via the adjusted Research and Development (RAND) 36-Item Health Survey 1.0patient reported

Polypharmacy is associated with a significantly lower physical and mental health-related quality of life in patients with hypertension.

Cite This Study

Paramba et al. (2022) studied this question.

synapsesocial.com/papers/6a87e45606b1cb81386c8a29https://doi.org/10.7759/cureus.30361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older2020 · 195 citations
  2. 2Awareness, medication adherence, and diet pattern among hypertensive patients attending teaching institution in western Rajasthan, India2020 · 6 citations
  3. 32020 International Society of Hypertension Global Hypertension Practice Guidelines2020 · 4,254 citations
  4. 4The RAND-36 measure of health-related quality of life2001 · 1,501 citations
  5. 5Appropriate Polypharmacy and Medicine Safety: When Many is not Too Many2015 · 306 citations