Describes a rare familial inherited arrhythmia characterized by nodal bradycardia and paroxysmal atrial fibrillation in adulthood.
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Identifies a rare familial nodal bradycardia-AF phenotype; leaves open its genetic basis and need for prospective family studies.
An unusual family group covering 3 generations is presented, all of whose members manifest a characteristic arrhythmia that appears to be an inherited trait. Each of the 9 known descendants exhibits a nodal bradycardia and each of the 4 descendants who have entered the fourth decade of life have also experienced paroxysms of atrial fibrillation. These paroxysms almost invariably terminate with the re-establishment of nodal rhythm. By history, the majority of these individuals are asymptomatic, and detailed examination of 2 adult members has failed to uncover evidence of specific cardiac disease. The problem of familial arrhythmia is briefly reviewed.
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Bacos et al. (1960) studied this question.
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