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January 24, 1966JAMA

Intramyocardial Lesions in Patients Dying Suddenly and Unexpectedly

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Why the study?

Does tranquilizer use associate with specific intramyocardial lesions in neuropsychiatric patients dying suddenly and unexpectedly?

Population

53 patients from a 2,000-bed neuropsychiatric hospital who died suddenly and unexpectedly, comprising 4…

Comparison

Tranquilizer use vs No tranquilizer use (nontranquilized patients)

Design

Case-control

Authors

HRHoward L. RichardsonEnvironmental Protection Agency

Discussion

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Implication

Tranquilizer use may associate with conduction lesions in sudden death; leaves open causality in case-control data.

Structured PICO

Does tranquilizer use associate with specific intramyocardial lesions in neuropsychiatric patients dying suddenly and unexpectedly?

P
Population
53 patients from a 2,000-bed neuropsychiatric hospital who died suddenly and unexpectedly, comprising 4 patients receiving tranquilizers and 49 nontranquilized patients.
I
Intervention
Tranquilizer use
C
Comparator
No tranquilizer use (nontranquilized patients)
O
Outcome
Presence and characteristics of intramyocardial lesions assessed via histochemical techniquessurrogate

Sudden unexpected death in psychiatric patients receiving tranquilizers may be linked to specific intramyocardial arteriolar lesions and acid mucopolysaccharide accumulation in the cardiac conduction system.

Cite This Study

Howard L. Richardson (1966) studied this question.

synapsesocial.com/papers/6a71fbdf26a7f98052de12f1https://doi.org/10.1001/jama.1966.03100040060017
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Also Consider

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  1. 1Acute Cardiac Death of Unknown Etiology A Preliminary Report1962 · 6 citations
  2. 2Thioridazine Hydrochloride (Mellaril): Its Effect on the Electrocardiogram and a Report of Two Fatalities with Electrocardiographic Abnormalities1963 · 187 citations
  3. 3Sudden Death During Treatment With Phenothiazine Derivatives1965 · 164 citations