Risk of depression is higher in elderly patients with lowest serum cholesterol values: Table 1

Renzo Rozzini; Bruno Bertozzi; Piera Barbisoni; Marco Trabucchi

doi:10.1136/bmj.312.7041.1298c

May 18, 1996BMJOpen Access

Risk of depression is higher in elderly patients with lowest serum cholesterol values: Table 1

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Why the study?

Does low serum cholesterol concentration increase the risk of depression in elderly patients?

Structured PICO

Does low serum cholesterol concentration increase the risk of depression in elderly patients?

P

Population

476 elderly patients consecutively admitted to a geriatric evaluation and rehabilitation unit over 12 months (mean age 78.8, 70% women).

I

Intervention

Low serum cholesterol concentration (<4.13 mmol/l)

C

Comparator

Higher serum cholesterol concentrations (>6.20 mmol/l and 4.14-6.19 mmol/l)

O

Outcome

Depression (defined as score on geriatric depression scale >10)patient reported

Low serum cholesterol concentrations are independently associated with a higher risk of depression in elderly hospitalized patients.

Limitations

Cannot confirm the mechanism proposed to explain the relation between low serum cholesterol and depression
Needs further confirmation in light of previously reported conflicting data

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Answers are grounded in this paper and cite their sources.

Implication

Should not yet alter lipid management in elderly inpatients; hypothesis-generating for causality and needs prospective confirmation.

Abstract

EDITOR,—We read with interest Paul H A Steegmans and colleagues' short report on serum cholesterol concentration and serotonin metabolism.1 We would like to add support to the hypothesis of an association between low serum cholesterol concentration and depression with data obtained in our geriatric evaluation and rehabilitation unit. Data in this study were taken from 476 elderly patients consecutively admitted to our unit over 12 months (mean age 78.8 (SD 7.4); 70% women). …

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Cite This Study

Rozzini et al. (1996) studied this question.

synapsesocial.com/papers/6a71ff55af0c21e93929425a https://doi.org/10.1136/bmj.312.7041.1298c

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Risk of depression is higher in elderly patients with lowest serum cholesterol values: Table 1

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Risk of depression is higher in elderly patients with lowest serum cholesterol values: Table 1

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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