Why the study?
Does MAPK inhibition reduce TPO-dependent proliferation and endomitosis in megakaryocytes?
Population
Cytokine-dependent cell line (BAF3/Mpl) and primary murine megakaryocytes (CD41+ cells from whole bone marrow)
Comparison
Thrombopoietin stimulation and MAPK kinase… vs Unstimulated cells or cells without MEK inhibitor
Design
Preclinical
Authors
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MAPK inhibition may modulate megakaryopoiesis; leaves open in vivo effects on platelet production.
Does MAPK inhibition reduce TPO-dependent proliferation and endomitosis in megakaryocytes?
The MAPK pathway plays an important role in TPO-induced endomitosis in megakaryocytes.
Rojnuckarin et al. (1999) studied this question.
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