July 1, 1998Molecular and Cellular BiologyOpen Access

Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line

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Population

F-36P-mpl cells (a human interleukin-3 (IL-3)-dependent erythroleukemia cell line transfected with c-mpl)

Comparison

Thrombopoietin treatment, inducible expression… vs IL-3 treatment or control conditions

Design

Preclinical

Authors

IMItaru MatsumuraKindai University Hospital KNKoichi NakajimaOsaka City University HWHiroshi WakaoDokkyo Medical University

Discussion

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Implication

May support Ras-targeted strategies in platelet disorders; leaves open validation beyond animal models.

Structured PICO

Population

F-36P-mpl cells (a human interleukin-3 (IL-3)-dependent erythroleukemia cell line transfected with c-mpl)

Intervention

Thrombopoietin (TPO) treatment, inducible expression of dominant-negative forms of STAT1, STAT3, STAT5, and ras, and overexpression of activated ras (H-rasG12V)

Comparator

IL-3 treatment or control conditions

Outcome

Cell proliferation and megakaryocytic differentiationsurrogate

Prolonged ras activation is a key mechanism underlying TPO-induced megakaryocytic differentiation in hematopoietic cells.

Cite This Study

Matsumura et al. (1998) studied this question.

synapsesocial.com/papers/6a8bce753c68152a7ce96f0c https://doi.org/10.1128/mcb.18.7.4282

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Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of Prolonged Ras Activation in Thrombopoietin-Induced Megakaryocytic Differentiation of a Human Factor-Dependent Hematopoietic Cell Line

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider