Key result
Overexpression of dominant negative cdc2 together with cyclin D1, cyclin D2, or cyclin D3 facilitated megakaryocytic differentiation in the absence of TPO in a human hematopoietic cell line.
Both D-type cyclin expression and decreased cdc2 kinase activity participate in megakaryocytic differentiation.
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Should not change clinical management of thrombopoiesis; leaves open cyclin D-cdc2 roles in megakaryocytic differentiation.
Matsumura et al. (2000) studied Megakaryocytic differentiation. Overexpression of dominant negative cdc2 together with cyclin D1, D2, or D3 was evaluated on Megakaryocytic differentiation. Overexpression of dominant negative cdc2 together with cyclin D1, cyclin D2, or cyclin D3 facilitated megakaryocytic differentiation in the absence of TPO in a human hematopoietic cell line.
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