Key result
Thrombopoietin-induced megakaryocytic differentiation of CMK cells involves the transcriptional activation of p21(WAF1/Cip1) mediated by STAT5.
TPO-induced megakaryocytic differentiation involves the transcriptional activation of the Cdk inhibitor p21 by STAT5.
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Cell line data on STAT5-p21 in megakaryopoiesis leaves open in vivo and clinical translation; extends molecular understanding of TPO signaling.
Matsumura et al. (1997) studied Megakaryoblastic leukemia. Thrombopoietin (TPO) vs. Medium alone was evaluated on Megakaryocytic differentiation and p21 induction. Thrombopoietin-induced megakaryocytic differentiation of CMK cells involves the transcriptional activation of p21(WAF1/Cip1) mediated by STAT5.
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