Why the study?
Renal leukocyte infiltration contributes to Dahl salt-sensitive hypertension and renal disease, but the signaling pathways guiding leukocyte trafficking to the kidneys remain poorly understood.
Does CCR2 antagonism with RS-102895 reduce renal damage and hypertension in Dahl salt-sensitive rats on a high-salt diet?
Population
Dahl salt-sensitive rats fed a high-salt (4.0% NaCl) diet
Comparison
CCR2 antagonist (RS-102895) vs DMSO vehicle
Design
Preclinical animal study
Follow-up
3 or 21 days
Authors
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Nominates chemotactic pathway for renal leukocyte infiltration in salt-sensitive hypertension; hypothesis-generating and requires functional validation.
Does CCR2 antagonism with RS-102895 reduce renal damage and hypertension in Dahl salt-sensitive rats on a high-salt diet?
Blockade of the CCL2/CCR2 pathway with RS-102895 blunts early renal leukocyte recruitment, subsequently reducing renal damage and hypertension in salt-sensitive rats.
Alsheikh et al. (2020) studied this question.
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