Population
Dahl salt-sensitive (DS) and Lewis (LEW) rats
Comparison
High-salt diet vs Normal diet / Lewis (LEW) rats
Design
Preclinical
Authors
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Ccl2/MCP-1 emerges as a candidate mediator of salt-sensitive hypertension in rats; leaves open its role and therapeutic relevance in humans.
The Ccl2 gene (encoding MCP-1) is a strong candidate gene for salt-sensitive hypertension and associated renal injury in Dahl salt-sensitive rats.
Yasui et al. (2007) studied this question.
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