December 1, 1989Circulation Research

Differences in load dependence of relaxation between the left and right ventricular myocardium as a function of age in rats.

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Population

Posterior papillary muscles from the left and right ventricles of Fischer and Sprague-Dawley rats at 4, 10…

Design

Preclinical

Authors

JCJ. M. CapassoUniversity of Parma EPE. PuntilloNew York Medical College GOG OlivettiHeart Failure & Transplant

Discussion

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Implication

Rat ventricular load differences caution against human extrapolation; leaves open strain-specific aging mechanisms for targeted validation studies.

Structured PICO

Population

Posterior papillary muscles from the left and right ventricles of Fischer and Sprague-Dawley rats at 4, 10, and 20 months of age

Intervention

In vitro assessment under variably loaded conditions

Outcome

Ratio of the duration of afterloaded isotonic shortening and relengthening to the time required for isometric force to decline to the same level during isometric relaxationsurrogate

Distinct differences exist in the mechanical dynamics of inactivation between the left and right ventricular myocardium, with strain-specific aging effects.

Cite This Study

Capasso et al. (1989) studied this question.

synapsesocial.com/papers/6a72062c26a7f98052de188c https://doi.org/10.1161/01.res.65.6.1499

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Implication

Rat ventricular load differences caution against human extrapolation; leaves open strain-specific aging mechanisms for targeted validation studies.

Differences in load dependence of relaxation between the left and right ventricular myocardium as a function of age in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differences in load dependence of relaxation between the left and right ventricular myocardium as a function of age in rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider