January 1, 2000Journal of the American Society of Nephrology

Nitric Oxide Synthase Isoforms and Glomerular Hyperfiltration in Early Diabetic Nephropathy

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Population

Conscious instrumented rats, 2 weeks after induction of diabetes mellitus by streptozotocin, and untreated…

Comparison

Intravenous administration of… vs Untreated normoglycemic control rats.

Design

Preclinical

Follow-up

2 weeks after induction of diabetes

Authors

RVRoland VeelkenFriedrich-Alexander-Universität Erlangen-Nürnberg KHKarl F. HilgersGeneral / Preventive / Lipids AHAndrea HartnerUniversitätsklinikum Erlangen

Discussion

Member takes

Implication

ecNOS may drive early diabetic hyperfiltration in rats; leaves open selective targeting in human nephropathy.

Structured PICO

Population

Conscious instrumented rats, 2 weeks after induction of diabetes mellitus by streptozotocin, and untreated normoglycemic control rats.

Intervention

Intravenous administration of L-imino-ethyl-lysine (L-NIL) (0.1, 1, and 10 mg) or NG-nitro-L-arginine methyl ester (L-NAME) (0.1, 1, and 10 mg).

Comparator

Untreated normoglycemic control rats.

Outcome

Mean arterial BP (MAP), GFR (inulin clearance), and renal plasma flow (RPF) (para-aminohippurate clearance).surrogate

Increased NO availability due to greater abundance of ecNOS, rather than iNOS, contributes to glomerular hyperfiltration in early experimental diabetic nephropathy.

Cite This Study

Veelken et al. (2000) studied this question.

synapsesocial.com/papers/6a72062e84cc45bb7be00c19 https://doi.org/10.1681/asn.v11171

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Nitric Oxide Synthase Isoforms and Glomerular Hyperfiltration in Early Diabetic Nephropathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric Oxide Synthase Isoforms and Glomerular Hyperfiltration in Early Diabetic Nephropathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider