A novel modified nucleoside, 5-carboxymethyluridine was isolated from 24 hour collection of urine from a lung carcinoma patient. The structure was assigned on the basis of UV, NMR and mass spectrometry, and confirmed by comparison of the spectral data and HPLC and paper chromatographic mobilities with those of the authentic sample. Possible origin and significance of this nucleoside is discussed.
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Tworek et al. (1986) studied this question.
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