Cardiac autonomic neuropathy in patients with diabetes and no symptoms of coronary artery disease: comparison of 123I-metaiodobenzylguanidine myocardial scintigraphy and heart rate variability
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Why the study?
Does 123I-mIBG myocardial scintigraphy detect cardiac autonomic neuropathy more frequently than heart rate variability in asymptomatic patients with type 2 diabetes?
Population
88 patients with type 2 diabetes, prospectively recruited from an outpatient clinic, truly asymptomatic for…
Comparison
123I-metaiodobenzylguanidine myocardial… vs Heart rate variability (HRV) assessment
Design
Cross-sectional, All Holter ECG recordings were analysed by two experienced…
Authors
Discussion
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Implication
123I-mIBG may detect subclinical cardiac autonomic neuropathy missed by HRV in asymptomatic type 2 diabetes; hypothesis-generating and requires prospective validation.
Structured PICO
Does 123I-mIBG myocardial scintigraphy detect cardiac autonomic neuropathy more frequently than heart rate variability in asymptomatic patients with type 2 diabetes?
P
Population
88 patients with type 2 diabetes, prospectively recruited from an outpatient clinic, truly asymptomatic for coronary artery disease (CAD) with normal myocardial perfusion, mean age 53, 64% male.
I
Intervention
123I-metaiodobenzylguanidine (123I-mIBG) myocardial scintigraphy
C
Comparator
Heart rate variability (HRV) assessment
O
Outcome
Prevalence of cardiac autonomic neuropathy (CAN) and agreement between HRV and 123I-mIBG scintigraphysurrogate
123I-mIBG myocardial scintigraphy detects cardiac autonomic neuropathy more frequently than heart rate variability in asymptomatic patients with type 2 diabetes, suggesting it may be a more sensitive early marker.
Limitations
- The current study included only diabetic patients, and no control population was available.
- Precise threshold values for diabetic patients and normal controls need to be further explored for the individual 123I-mIBG variables.
- Variation in the individual values appears to be substantial.
Cite This Study
Scholte et al. (2010) studied this question.
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