Why the study?
Does administration of atrial natriuretic extracts alter systemic and regional hemodynamics in conscious WKY and SHR rats?
Population
Conscious Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats
Comparison
Partially purified low and high… vs Baseline and comparison between strains and…
Design
Preclinical
Follow-up
30 minutes
Authors
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Hypothesis-generating in conscious rats; leaves open translation of LMW/HMW atrial extract effects to human hemodynamics.
Does administration of atrial natriuretic extracts alter systemic and regional hemodynamics in conscious WKY and SHR rats?
Atrial natriuretic extracts produce distinct systemic and regional hemodynamic effects in conscious rats, including decreased mean arterial pressure and cardiac output, which differ markedly from typical vasodilators.
Pegram et al. (1985) studied this question.
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