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January 1, 1975Intervirology

Size of the Poly(A) Sequences in Encephalomyocarditis Virus RNA

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Population

Encephalomyocarditis (EMC) virus RNA

Design

Preclinical

Authors

MGMarie-Lou GironFLF. LogeatNHNicole Hanania

Discussion

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Overview

No direct clinical implications for viral heart disease; extends molecular virology of picornaviruses for future study.

Structured PICO

P
Population
Encephalomyocarditis (EMC) virus RNA
I
Intervention
Affinity chromatography on poly(U)-Sepharose, treatment with RNases, reverse transcription priming, alkaline hydrolysis, and snake venom phosphodiesterase digestion
O
Outcome
Size and location of poly(A) sequencessurrogate

The study identifies that poly(A) sequences in encephalomyocarditis virus RNA are 10-20 nucleotides long and located at the 3' end.

Cite This Study

Giron et al. (1975) studied this question.

synapsesocial.com/papers/6a7209e4febe604dd70a68behttps://doi.org/10.1159/000149493
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Size and location of poly (A) in encephalomyocarditis virus RNA1976 · 13 citations
  2. 2The Size and Location of the Poly(A) Tract in EMC Virus RNA1977 · 16 citations
  3. 3Encephalomyocarditis virus RNA. II. Polyadenylic acid requirement for efficient translation1977 · 18 citations
  4. 4The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region1984 · 234 citations
  5. 5Requirement of an Adenylic Acid-Rich Segment for the Infectivity of Encephalomyocarditis Virus RNA1976 · 27 citations