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October 1, 1976Nucleic Acids ResearchOpen Access

Size and location of poly (A) in encephalomyocarditis virus RNA

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Population

Encephalomyocarditis (EMC) virus RNA grown in Krebs ascites cells

Design

Preclinical

Authors

DFDavid FrisbyThe Honourable Society of Lincoln's InnJSJ. SmithVJValjeanne Jeffers

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Overview

Characterizes EMCV RNA in a myocarditis model; leaves open translation to human enteroviral disease.

Structured PICO

P
Population
Encephalomyocarditis (EMC) virus RNA grown in Krebs ascites cells
I
Intervention
Biochemical analysis including two-dimensional gel electrophoresis, alkaline hydrolysis, formamide-polyacrylamide gel electrophoresis, [3H-]poly(U) hybridization, and [3H-]isoniazid labelling
O
Outcome
Size and location of the poly(A) sequence in EMC virus RNAsurrogate

The study demonstrates that the poly(A) sequence of encephalomyocarditis virus RNA is approximately 40 nucleotides long and located at the 3'-terminus.

Cite This Study

Frisby et al. (1976) studied this question.

synapsesocial.com/papers/6a723e2ea7fbea1e44089fabhttps://doi.org/10.1093/nar/3.10.2789
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ribonucleic Acid Content of Encephalomyocarditis Virus1970 · 30 citations
  2. 2Poly(A) on mengovirus RNA1975 · 13 citations
  3. 3Polypeptide cleavages in the formation of poliovirus proteins.1968 · 351 citations
  4. 4Translational Properties of Rabbit Globin mRNA after Specific Removal of Poly(A) with Ribonuclease H1974 · 87 citations
  5. 5Polyriboadenylate Sequences at the 3′-Termini of Ribonucleic Acid Obtained from Mammalian Leukemia and Sarcoma Viruses1974 · 11 citations