Population
Isolated rat myocytes
Comparison
Preconditioning with either two cycles of 5… vs Anoxic controls
Design
Preclinical
Follow-up
60 minutes or 24 hours
Authors
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May enhance late cardioprotection via antioxidant induction; extends preclinical mechanisms but leaves clinical translation open.
Initial oxidative stress generated during brief, repetitive anoxia increases myocardial antioxidant activity 24 hours later, contributing to the late cardioprotective effect of preconditioning.
Zhou et al. (1996) studied this question.
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