Why the study?
How do kainic acid-induced limbic cortical seizures affect cardiac sympathetic nerve activity in rats?
How do kainic acid-induced limbic cortical seizures affect cardiac sympathetic nerve activity in rats?
Limbic cortical seizures disrupt the normal relationship between ventilation and cardiac sympathetic nerve activity, which may contribute to autonomic dysregulation of the heart during seizures.
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May indicate autonomic dysregulation during seizures in this model; hypothesis-generating for SUDEP mechanisms, pending human studies.
Hotta et al. (2008) studied this question.
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