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July 1, 1987American Journal of Tropical Medicine and Hygiene

Field Trial of Vaccination against American Trypanosomiasis (Chagas' Disease) in Domestic Guinea Pigs

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Why the study?

Does vaccination with live attenuated T. cruzi epimastigotes reduce natural T. cruzi infection in domestic guinea pigs?

Population

102 domestically bred South American guinea pigs

Comparison

3 to 5 immunizing intradermal inocula of 28 X 10… vs Control guinea pigs

Design

Preclinical

Follow-up

up to 551 days

Authors

MBMiguel Á. BasombríoNational University of SaltaHAHugo R. ArredesNational University of SaltaDUD. A. Uncos

Discussion

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Implication

Animal data suggest partial protection; leaves open translation to human Chagas disease prevention.

Structured PICO

Does vaccination with live attenuated T. cruzi epimastigotes reduce natural T. cruzi infection in domestic guinea pigs?

P
Population
102 domestically bred South American guinea pigs
I
Intervention
3 to 5 immunizing intradermal inocula of 28 X 10(6) live attenuated Trypanosoma cruzi epimastigotes (TCC strain) per kg
C
Comparator
Control guinea pigs
O
Outcome
Incidence of natural T. cruzi infection

Vaccination with live attenuated T. cruzi epimastigotes partially protects guinea pigs against natural infection and reduces vector transmission rates.

Cite This Study

Basombrío et al. (1987) studied this question.

synapsesocial.com/papers/6a720fdea7fbea1e440893d0https://doi.org/10.4269/ajtmh.1987.37.57
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevention of electrocardiographic and histopathologic alterations in the murine model of Chagas' disease by preinoculation of an attenuated Trypanosoma cruzi strain1989 · 10 citations
  2. 2Clinical and histopathological changes of some vital organs associated with intra-peritoneal experimental infection with Trypanosoma evansi in Guinea pigs2025
  3. 3Vaccination with parasite-specific TcTASV proteins combined with recombinant baculovirus as a delivery platform protects against acute and chronic Trypanosoma cruzi infection2024 · 8 citations
  4. 4α-Gal immunization positively impacts Trypanosoma cruzi colonization of heart tissue in a mouse model2021 · 17 citations
  5. 5Prevalence of Trypanosoma cruzi Antibodies in Wild Pigs (Sus scrofa) in the USA2025